ea0033p18 | (1) | BSPED2013
Shi Yanqin
, Avatapalle Hima B
, Skae Mars S
, Padidela Raja
, Newbould Melanie
, Rigby Lindsey
, Flanagan Sarah E
, Ellard Sian
, Rahier Jacques
, Clayton Peter E
, Banerjee Indraneel
, Dunne Mark J
, Cosgrove Karen E
Introduction: Congenital hyperinsulinism (CHI) may arise due to loss-of-function mutations in ABCC8 and KCNJ11 genes which encode subunits of ATP-sensitive potassium (KATP) channels. KATP channels couple nutrient metabolism with insulin secretion in pancreatic β-cells but are also located in enteroendocrine L- and K-cells and may play a role in the control of GLP-1 and GIP secretion respectively. More than 70% of patients with CHI h...